Course: The Human Microbiome in Well being and Illness


In collaboration with the Primal Well being Coach Institute, I’ve put collectively a complete academic course on the microbiome known as The Human Microbiome in Well being and Illness. The course is designed for well being coaches to empower them in advising shoppers and sufferers on points microbiome. It’s, I consider, essentially the most complete and full course of its sort. Whereas designed for well being coaches, it may possibly additionally present deep training on all microbiome points for different well being professionals, physicians, or the well-informed citizen scientist or anybody with a deep curiosity in these vital points.

As a result of the science exploring the human microbiome is rising so quickly, most individuals in healthcare have turn out to be helplessly out-of-date. But insights into the microbiome are proving to be one of the vital vital revolutions in well being to emerge in a few years. It’s altering virtually every little thing we thought we knew about well being and illness, re-defining well being situations as widespread as kind 2 diabetes, weight problems, hypertension, coronary heart illness, colon most cancers, and cognitive impairment.

The course is delivered over 9 modules, every beginning with a video overview, consists of graphics and diagrams, well being teaching suggestions, and chosen references for additional exploration. Word that Members of my Internal Circle may even be offered entry to the same, expanded course near-future.

Right here is the final format of the course:

Module 1: Overview
Fundamental gastrointestinal (GI) anatomy and physiology from a microbiome perspective
Microbiome in well being—places, concentrations, species: micro organism, archaea, fungi, viruses, phages
Microbiome in illness—main, secondary; causative or exacerbating roles; metabolites
Strategies of evaluation—stool microbiome evaluation; breath testing; empiric strategies
Why the science has progressed quickly simply over the previous decade—tradition strategies, 16s rRNA sequencing, shotgun metagenomics
Human Microbiome Undertaking, Meta-HIT
Why examine the microbiome, what well being benefits are doable?

Module 2: Fundamental microbiology
Micro organism, fungi, archaea, bacteriophages
Gram constructive, Gram destructive
Asexual replica, fermentation
Lipopolysaccharide, lipoteichoic acid, beta glucan
Introduction to endotoxemia and translocation

Module 3: Human GI anatomy and physiology from a microbiome perspective
Mouth, enamel, oropharynx—salivary elements; reservoir of microbes in regular vs. decay/gingivitis/periodontitis
Esophagus—propulsive motion, esophageal sphincter
Abdomen—Function of abdomen acid, parietal cells, H pylori, intrinsic issue
Duodenum—widespread bile duct, cholecystokinin, alkalization, bile, pancreatic enzymes; susceptibility to microbial disruption
Jejunum, ileum—mucus barrier, intestinal immune system, myenteric nervous system, vagus nerve; distinctive microbial surroundings; migrating motor advanced—is that this an actual subject?
Colon—cecum, appendix, ascending, transverse, descending, sigmoid

Module 4: Gastrointestinal microbiome in well being
Is there such a factor as a “wholesome microbiome”? Judgements based mostly on assessments of indigenous hunter-gatherer populations—Do they characterize the optimum scenario or variations to native environments?
Wholesome fashionable microbial populations—GI places, concentrations, and features of micro organism, fungi, archaea
Capabilities—intestinal mucus stimulation, competitors with pathogens, meals processing, participation in intestinal immune operate
Quick-chain fatty acid metabolites
Vitamin metabolites—B nutritional vitamins, K2
Bile acid metabolites—position of taurine, glycine; bile salt hydrolase
Idea of keystone species and position in sustaining a wholesome microbiome
Evolution of the microbiome from beginning, to infancy, to early childhood, to maturity, to aged
Modifications related to being pregnant and lactation
Fundamentals of gastrointestinal mucus

Module 5: The disrupted microbiome and its position in human illness
Core microbiota; relative populations of Bacteroidetes, Firmicutes, Actinobacteria, Proteobacteria, and Verrucomicrobia; adjustments in species composition
Overgrowth of micro organism, fungi, archaea
Key markers—Bacteroidetes/firmicutes ratio; proportion Verrucomicrobia/Akkermansia; proportion Faecalibacterium prausnitzii; Fusobacterium nucleatum; Ruminococcaceae, Lachnospiraceae, Clostridia; Proteobacteria—E. coli, Klebsiella, Enterobacter, and so forth.; Gram positives—Staphylococcus, Streptococcus, Enterococcus
Elements that disrupt microbiome composition—antibiotics, different prescribed drugs, meals components (emulsifiers, preservatives) herbicides/pesticides, glyphosate, chlorinated ingesting water, artificial sweeteners, stress, electromagnetic frequencies?
Penalties of lack of prebiotic fibers and different microbial vitamins
Modifications in species location—colon vs small bowel, bacterial translocation
Disrupted microbial composition, disrupted intestinal mucus barrier, intestinal permeability, serum LPS, serum zonulin
Metabolic endotoxemia and its broad penalties
That means of meals intolerances—histamine containing meals, nightshades, FODMAPs, fructose, legumes, nuts

Module 6: The microbiome in varied illness states
Gallstones and bacterial infestation
Pancreatic exocrine insufficiency
Gingivitis, periodontitis—together with the colon connection by way of Fusobacterium nucleatum as a explanation for colon most cancers
Irritable bowel syndrome (IBD)
Inflammatory bowel illness
Celiac illness, “non-celiac gluten sensitivity”
Kind 2 diabetes, chubby/weight problems
Autoimmune illnesses
Neurodegenerative illnesses
Heart problems
Problems of being pregnant and lactation
Bariatric procedures together with gastric bypass

Module 7: Strategies of microbiome evaluation
Symptom evaluation
Stool evaluation—reliability, strategies (16S rRNA vs. shotgun metagenomics), microbial analyses, physiologic markers. We assessment a number of actual world examples throughout totally different testing platforms—e.g., Genova, Ombre, Viome, Intestine Zoomer.
Breath testing—hydrogen, methane, hydrogen sulfide, AIRE gadget, Trio-Good

Module 8: Concentrate on types of overgrowth
Small intestinal bacterial overgrowth (SIBO)—signs; endotoxemia, systemic illness implications; evaluation; eradication; prevention of recurrences
Small intestinal fungal overgrowth (SIFO)—signs; beta glucan, systemic illness implications; evaluation; eradication; prevention of recurrences
Intestinal methanogen overgrowth (IMO)—signs; evaluation; eradication

Module 9: Methods and instruments for microbiome administration
Probiotics–composition, rationale, ineffectiveness; future instructions
Fermented meals–offering the microbiome-”molding” results of vital fermenting species corresponding to Leuconostoc and Pediococcus species; fundamentals of fermentation
Prebiotic fibers, polysaccharides, polyphenols
Fecal transplant and associated strategies
Restoration of keystone species, higher GI colonization, bacteriocin manufacturing

Closing feedback, overview, future instructions
Assets to comply with new developments
Assets for continued suggestions and assist
Microbe sources for fermentation
Recipes for chosen microbial ferments

In case you are considering enrolling on this course (it’s open to non-health coaches, additionally, in addition to medical doctors, different well being professionals, or for anybody considering an in depth dialogue in regards to the microbiome), enroll right here.


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